This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including pr...
2/12/2015 9:45:51 PM
Thymic stromal lymphopoietin (TSLP) is a cytokine released by human lung epithelium in response to external insult. Considered as a master switch in T helper 2 lymphocyte (Th2) mediated responses, TSLP is believed to play a key role in allergic diseases including asthma. The ...
1/24/2020 10:29:02 AM
Phenotypic or biofunctional assays play an important role in drug discovery by helping to bridge the gap between high-throughput, target-based screening assays used for compound identification and more physiologically relevant in vivo disease models used for preclinical dev...
4/8/2019 4:20:34 PM
Improving the safety of drug candidates that enter clinical development requires assays that are more predictive of human outcomes. The BioMAP® platform uses human primary cells to model complex aspects of disease and tissue biology and can be applied to better understand biol...
2/7/2014 10:59:34 PM
We have applied a panel of primary human cell-based in vitro systems (the BioMAP® systems platform) that model complex aspects of disease and tissue biology to investigate the biological mechanisms that underlie certain drug adverse effects. Here we present the analysis of sev...
1/18/2013 11:49:23 PM
Pages: 1 of 2