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Plk1, active

/products/proteins/14-777
Plk1, active

/products/proteins/14-777m
polo-like kinase 1 (PLK1)
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/...
/target-data-sheets/kinase/plk1 2/12/2015 9:48:03 PM
Wortmannin

/products/reagent/wortmannin-92-1095
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies. The difficulty of discovering kinase inhibitors with an appropriate multitarget profile has, however, necessitated the a...
/tools-resources/publications-references/publications/dual-kinase-bromodomain-inhibitors-polypharmacolog 4/8/2019 4:01:01 PM
[2014 AACR Poster] Dual kinase/bromodomain inhibitors for rationally designed polypharmacology
Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies.   The difficulty of discovering kinase inhibitors with an appropriate multi-target profile has, however, necessitated ...
/tools-resources/document-resource-library/documents/cell-based-receptor-tyrosine-kinase-screening-(1) 4/16/2014 9:22:40 PM
[2014 DDC Conference] Rational design of dual kinase-bromodomain inhibitors for therapeutic polypharmacology
We recently reported that several clinical kinase inhibitors also inhibit bromodomain epigenetic reader proteins with therapeutically relevant potencies (Nat. Chem. Biol. (2014) doi: 10.1038/nchembio.1471). Nanomolar activity on BRD4 by BI-2536 and TG-101348, clinical...
/tools-resources/document-resource-library/documents/cell-based-receptor-tyrosine-kinase-screening-(3) 4/30/2014 10:19:22 PM
Dual kinase/bromodomain inhibitors for rationally designed polypharmacology
Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies. The difficulty of discovering kinase inhibitors with an appropriate multi-target profile has, however, necessitated the a...
/tools-resources/document-resource-library/documents/dual-kinase-bromodomain-inhibitors-for-rationally 1/23/2014 9:36:34 PM
Gene Symbol
KINOME scan Gene Symbol td:first-child { background-color:#FFFFCC; } KINOMEscan Gene Symbol Entrez Gene Symbol Accession Number AAK1 AAK1 NP_055726.3 ABL1(E255K)-phosphorylated ABL1 NP_005148.2 ABL1(F317I)...
/services/drug-discovery-development-services/kinase-profiling/kinomescan/gene-symbol 3/4/2016 8:11:57 PM
Available Cysteine Kinases
Find a Product "Cysteinome" Assay Portfolio - potential targets for the rational development of irreversible inhibitors In a recent publication ( Liu Q., et.al . 2013 ) they identify almost 200 kinases that contain a reactive nucleophilic cysteine residue near the ATP bin...
/targets/kinase-target-biology/cysteine-kinases 10/10/2014 5:14:34 PM
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