/products/proteins/14-777
/products/proteins/14-777m
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/...
/target-data-sheets/kinase/plk1
2/12/2015 9:48:03 PM
/products/reagent/wortmannin-92-1095
Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies. The difficulty of discovering kinase inhibitors with an appropriate multitarget profile has, however, necessitated the a...
/tools-resources/publications-references/publications/dual-kinase-bromodomain-inhibitors-polypharmacolog
4/8/2019 4:01:01 PM
Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies. The difficulty of discovering kinase inhibitors with an appropriate multi-target profile has, however, necessitated the a...
/tools-resources/document-resource-library/documents/dual-kinase-bromodomain-inhibitors-for-rationally
1/23/2014 9:36:34 PM
KINOME scan Gene Symbol td:first-child { background-color:#FFFFCC; } KINOMEscan Gene Symbol Entrez Gene Symbol Accession Number AAK1 AAK1 NP_055726.3 ABL1(E255K)-phosphorylated ABL1 NP_005148.2 ABL1(F317I)...
/services/drug-discovery-development-services/kinase-profiling/kinomescan/gene-symbol
3/4/2016 8:11:57 PM
Find a Product "Cysteinome" Assay Portfolio - potential targets for the rational development of irreversible inhibitors In a recent publication ( Liu Q., et.al . 2013 ) they identify almost 200 kinases that contain a reactive nucleophilic cysteine residue near the ATP bin...
/targets/kinase-target-biology/cysteine-kinases
10/10/2014 5:14:34 PM
Selective protein kinase inhibitors have only been developed against a small number of kinase targets. Here we demonstrate that "high-throughput kinase profiling" is an efficient method for the discovery of lead compounds for established as well as unexplored kinase targets. W...
/tools-resources/publications-references/publications/high-throughput-kinase-profiling-a-more-efficient
10/3/2012 5:51:27 PM