Search Product
Contact a Specialist

/products/cell-line/hek-293-pi3kδ-kinase-binding-cell-line-96-0061c1
SLE is a complex autoimmune inflammatory disease characterized by pathogenic autoantibody production as a consequence of uncontrolled T–B cell activity and immune-complex deposition in various organs, including kidney, leading to tissue damage and function loss. There is a hi...
/tools-resources/publications-references/publications/pi3kδ-inhibitors-therapeutics-sle-preclinical 4/8/2019 4:10:30 PM
PI3Kδ and PI3Kγ regulate immune cell signaling, while the related PI3Kα and PI3Kβ regulate cell survival and metabolism. Selective inhibitors of PI3Kδ/γ represent a potential class of anti-inflammatory agents lacking the antiproliferative effects associated with PI3Kα/β inhib...
/tools-resources/publications-references/publications/dual-pi3ks-inhibitors-anti-inflammatory-prototype 4/8/2019 3:20:40 PM
BioMAP ®  Human Primary Cell Phenotypic Profiling Services     Overview of the BioMAP Platform BioMAP profiling is the broadest, most physiologically relevant method to quickly and robustly determine the efficacy, safety, and mechanism of action (MOA) of...
/services/drug-discovery-development-services/primary-cell-phenotypic-profiling 9/24/2013 10:39:16 PM
BioMAP ®  Human Primary Cell Phenotypic Profiling Services Overview of the BioMAP Platform BioMAP profiling is the broadest, most physiologically relevant method to quickly and robustly determine the efficacy, safety, and mechanism of action (MOA) of candidate d...
/tools-resources/drug-discovery-development-services/primary-cell-phenotypic-profiling 4/29/2020 10:04:12 AM
Addressing the safety aspects of drugs and environmental chemicals has historically been undertaken through animal testing. However, the quantity of chemicals in need of assessment and the challenges of species extrapolation require the development of alternative approaches. ...
/tools-resources/publications-references/publications/phenotypic-screening-toxcast-classification 4/8/2019 4:15:43 PM