Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis...
/target-data-sheets/checkpoint/pd-l1
12/4/2015 11:45:56 PM
/products/cell-line/u2os-pd-l1-pd-l1-dimerization-cell-line
Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis...
/target-data-sheets/checkpoint/pd-l1-pd-l1
2/7/2018 5:46:14 PM
/products/cell-line/u2os-pd-l1-ligand-cell-line-93-1066c3
/products/cell-line/u2os-pd-l1-tcr-activator-ligand-cell-lin-93-1154c3
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked t...
/tools-resources/publications-references/publications/the-engineered-cd80-variant-fusion-therapeutic-dav
5/24/2022 11:38:03 PM
Applications Assay Principle Assay Highlights Advantages of Checkpoint Assays PathHunter checkpoint assays are MOA-reflective assays for quantifying a functional response as a result of direct ligand binding to its checkpoint receptor. These cell-based assays enable rapid s...
/targets/checkpoint-assays
4/29/2020 4:06:29 PM
/products/reagent/anti-pd-l1-antibody-92-1340
Assay List Accelerate Cancer Immunotherapy Drug Development by Outsourcing Your Screening and Potency Needs Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefo...
/services/drug-discovery-development-services/immuno-oncology-profiling
7/29/2016 9:26:09 PM
Applications Target-Based Bioassays Assay Highlights Advantages of Bioassay Bioassays are ideal for determining drug potency and stability using a simple, mix-&-read protocol that reflects the drug’s clinical mechanism of action. These rapid cell-based assays bypass the need...
/products-applications/cell-based-assays-for-biologics
9/21/2017 8:11:42 PM
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