Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires ...
/target-data-sheets/gpcr/gpr109a
2/12/2015 9:44:11 PM
/products/reagent/nicotinic-acid-92-1168
/products/cell-line/stable-cell-line/hts201c
/products/frozen-cells/hts201rta
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This ph...
/target-data-sheets/gpcr/gpr109b
2/12/2015 9:44:11 PM
/products/assay/gpr109a-cho-k1-gpcr-assay-95-0122e2cp2m
/products/assay/gpr109a-cho-k1-gpcr-assay-95-0122e2cp2l
/products/assay/gpr109a-cho-k1-β-arrestin-gpcr-assay-93-0301e2cp2m
/products/assay/gpr109a-cho-k1-β-arrestin-gpcr-assay-93-0301e2cp2l
The alpha7 nicotinic acetylcholine receptor (nAChR) is a promising target for treatment of cognitive dysfunction associated with Alzheimer's disease and schizophrenia. Here, we report the pharmacological properties of 5-morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-ami...
/tools-resources/publications-references/publications/procognitive-and-neuroprotective-activity-of-a-nov
10/3/2012 5:51:16 PM
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