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Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells.
Lysophosphatidylinositol (LPI) is an endogenous ligand for GPR55, a putative novel type of cannabinoid receptor. In this study, we first examined the effects of LPI on p38 mitogen-activated protein kinase in HEK293 cells expressing GPR55. LPI induced the rapid phosphorylation ...
/tools-resources/publications-references/publications/lysophosphatidylinositol-induces-rapid-phosphoryla 10/3/2012 5:50:58 PM
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.
A growing number of orphan G-protein-coupled receptors (GPCRs) have been reported to be activated by lipid ligands, such as lysophosphatidic acid, sphingosine 1-phosphate (S1P), and cannabinoids, for which there are already well established receptors. These new ligand claim...
/tools-resources/publications-references/publications/lipid-g-protein-coupled-receptor-ligand-identifica 10/3/2012 5:50:41 PM
The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55.
Lysophosphatidylinositol (LPI) is a subspecies of lysophospholipid and is assumed to be not only a degradation product of phosphatidylinositol (PI), but also a bioactive lysophospholipid mediator. However, not much attention has been directed toward LPI compared to lysophos...
/tools-resources/publications-references/publications/the-actions-and-metabolism-of-lysophosphatidylinos 8/24/2015 3:11:07 PM
A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function.
The G protein-coupled receptor 55 (GPR55) is a lysophosphatidylinositol (LPI) receptor that is also responsive to certain cannabinoids. Although GPR55 has been implicated in several (patho)physiologic functions, its role remains enigmatic owing mainly to the lack of selecti...
/tools-resources/publications-references/publications/a-selective-antagonist-reveals-a-potential-role-of 8/20/2015 5:37:24 PM
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