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Janus kinase 1 (JAK1(JH1domain-catalytic))
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein k...
/target-data-sheets/kinase/jak1(jh1domain-catalytic) 2/12/2015 9:47:15 PM
Janus kinase 2 (JAK2(JH1domain-catalytic))
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an a...
/target-data-sheets/kinase/jak2(jh1domain-catalytic) 2/12/2015 9:47:16 PM
JAK2, active

/products/proteins/14-640
JAK2, active

/products/proteins/14-640m
Janus kinase 3 (JAK3(JH1domain-catalytic))
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via t...
/target-data-sheets/kinase/jak3(jh1domain-catalytic) 2/12/2015 9:47:16 PM
tyrosine kinase 2 (TYK2(JH1domain-catalytic))
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunit...
/target-data-sheets/kinase/tyk2(jh1domain-catalytic) 2/12/2015 9:48:34 PM
Erythropoietin receptor (EpoR)

/target-data-sheets/cytokine/epor-jak2 2/12/2015 9:43:53 PM
Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.
Janus kinase 2 (JAK2) signal transduction is a critical mediator of the immune response. JAK2 is implicated in the onset of graft-versus-host disease (GVHD), which is a significant cause of transplant-related mortality after allogeneic hematopoietic cell transplantation (allo...
/tools-resources/publications-references/publications/jak2-gvhd-xenograft-rejection-t-cell-differentiati 8/21/2020 10:58:04 PM
Janus kinase 1 (JAK1(JH2domain-pseudokinase))
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein k...
/target-data-sheets/kinase/jak1(jh2domain-pseudokinase) 2/12/2015 9:47:16 PM
Growth hormone receptor (GHR-JAK2)
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leadi...
/target-data-sheets/kinase/ghr-jak2 2/12/2015 9:44:07 PM
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