/products/proteins/14-466
/products/proteins/14-466m
/products/proteins/14-803
/products/proteins/14-803m
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encod...
/target-data-sheets/kinase/insr
2/12/2015 9:47:13 PM
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding diff...
/target-data-sheets/kinase/ltk
2/12/2015 9:47:23 PM
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in ...
/target-data-sheets/gpcr/gipr
2/12/2015 9:44:08 PM
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
/target-data-sheets/kinase/sik2
2/12/2015 9:48:21 PM
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function ...
/target-data-sheets/kinase/ros1
2/12/2015 9:48:14 PM
/products/proteins/14-645
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