Members of the G protein-coupled receptor (GPR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell (Sawzdargo et al., 1999 [PubMed 9931487]).[supplied by OMIM, Apr 2008]
/target-data-sheets/gpcr/gpr55
2/12/2015 9:44:22 PM
The orphan G-protein-coupled receptor GPR55, which is activated by 1-lysophosphatidylinositol and interacts with cannabinoid (CB) receptor ligands, has been proposed as a new potential drug target for the treatment of diabetes, Parkinson's disease, neuropathic pain, and can...
/tools-resources/publications-references/publications/antagonists-for-the-orphan-g-protein-coupled-recep
8/20/2015 6:25:46 PM
The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family of signal transducers, comprised of ∼1000 members. Considering their prevalence and functional importance, it’s not surprising that ∼60% of drugs target GPCRs. Regardless, there exi...
/tools-resources/publications-references/publications/the-therapeutic-potential-of-orphan-gpcrs-gpr35-an
8/20/2015 5:29:42 PM
/products/cell-line/cho-k1-gpr55-β-arrestin-cell-line-93-0245c2
Lysophosphatidylinositol (LPI) is a subspecies of lysophospholipid and is assumed to be not only a degradation product of phosphatidylinositol (PI), but also a bioactive lysophospholipid mediator. However, not much attention has been directed toward LPI compared to lysophos...
/tools-resources/publications-references/publications/the-actions-and-metabolism-of-lysophosphatidylinos
8/24/2015 3:11:07 PM
Lysophosphatidylinositol (LPI) is an endogenous ligand for GPR55, a putative novel type of cannabinoid receptor. In this study, we first examined the effects of LPI on p38 mitogen-activated protein kinase in HEK293 cells expressing GPR55. LPI induced the rapid phosphorylation ...
/tools-resources/publications-references/publications/lysophosphatidylinositol-induces-rapid-phosphoryla
10/3/2012 5:50:58 PM
The G protein-coupled receptor 55 (GPR55) is a lysophosphatidylinositol (LPI) receptor that is also responsive to certain cannabinoids. Although GPR55 has been implicated in several (patho)physiologic functions, its role remains enigmatic owing mainly to the lack of selecti...
/tools-resources/publications-references/publications/a-selective-antagonist-reveals-a-potential-role-of
8/20/2015 5:37:24 PM
GPR18 and GPR55 are orphan G protein-coupled receptors (GPCRs) that interact with certain cannabinoid (CB) receptor ligands. In the present study bicyclic imidazole-4-one derivatives were discovered as new scaffolds for the development of antagonists for GPR18 and GPR55. In...
/tools-resources/publications-references/publications/bicyclic-imidazole-4-one-derivatives-a-new-class-o
8/19/2015 4:24:30 PM
Magnolol (4-allyl-2-(5-allyl-2-hydroxyphenyl)phenol), the main bioactive constituent of the medicinal plant Magnolia officinalis, and its main metabolite tetrahydromagnolol were recently found to activate cannabinoid (CB) receptors. We now investigated the structure-activit...
/tools-resources/publications-references/publications/the-natural-product-magnolol-as-a-lead-structure-f
8/19/2015 4:30:53 PM
/products/reagent/lpi-(soy)-l-a-lysophosphatidylinositol-92-1120
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