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G-protein coupled receptor 132 (GPR132)
This gene encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels...
/target-data-sheets/gpcr/gpr132 2/12/2015 9:44:13 PM
PathHunter® CHO-K1 GPR132 β-Arrestin Orphan GPCR Cell Line

/products/cell-line/cho-k1-gpr132-β-arrestin-orphan-gpcr-ce-93-0411c2a
PathHunter® eXpress GPR132 CHO-K1 β-Arrestin Orphan GPCR Assay

/products/assay/gpr132-cho-k1-β-arrestin-orphan-gpc-93-0411e2acp1m
PathHunter® eXpress GPR132 CHO-K1 β-Arrestin Orphan GPCR Assay

/products/assay/gpr132-cho-k1-β-arrestin-orphan-gpc-93-0411e2acp1l
Identification of the first surrogate agonists for the G protein-coupled receptor GPR132.
GPR132 is an orphan class A G protein-coupled receptor. It has been proposed to be activated by protons and to regulate apoptosis, atherosclerosis and inflammation, but these results are still preliminary. In the current work, we designed and screened a focused compound l...
/tools-resources/publications-references/publications/identification-of-the-first-surrogate-agonists-for 9/21/2015 8:25:58 PM
Review: Free fatty acid receptors: emerging targets for treatment of diabetes and its complications
Fatty acids (FAs) are important as metabolic substrates and as structural components of biological membranes. However, they also function as signalling molecules. Recently, a series of G protein-coupled receptors (GPRs) for FAs has been described and characterized. These recep...
/tools-resources/publications-references/publications/review-free-fatty-acid-receptors-emerging-targets 10/3/2012 5:51:03 PM
GPCR Screening and Profiling Services
PathHunter ® GPCR Screening and Profiling Services Choose the Best Molecules for Preclinical and Clinical Study Developing and validating cell-based assays during drug discovery is expensive and can take months to complete. However, data is needed in days or weeks instead...
/services/drug-discovery-development-services/gpcr-screening-profiling-services 3/14/2017 8:39:57 PM
PathHunter Cell-Based Services
PathHunter ® Screening & Profiling Services Discover Next Generation Targeted Therapeutics with Cell-Based Functional Assays Choose the Best Molecules for Preclinical and Clinical Study Eurofins DiscoverX’s PathHunter Screening and Profiling Services offers greate...
/services/drug-discovery-development-services/pathhunter-cell-based-services 4/12/2017 5:42:47 PM
Review: Hydroxyoctadecadienoic acids: novel regulators of macrophage differentiation and atherogenesis
Hydroxyoctadecadienoic acids (HODEs) are stable oxidation products of linoleic acid, the generation of which is increased where oxidative stress is increased, such as in diabetes. In early atherosclerosis, 13-HODE is generated in macrophages by 15-lipoxygenase-1. This enhances...
/tools-resources/publications-references/publications/review-hydroxyoctadecadienoic-acids-novel-regulato 10/3/2012 5:51:04 PM
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