/products/reagent/fty720-phosphate-92-1104
This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a ro...
/target-data-sheets/gpcr/medg1
2/12/2015 9:44:59 PM
BACKGROUND AND PURPOSE: The molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated whether receptor binding kinetics and β-ar...
/tools-resources/publications-references/publications/investigating-the-molecular-mechanisms-through-whi
9/14/2015 10:00:16 PM
BACKGROUND AND PURPOSE: DiscoverRx's PathHunter assay measures GPCR agonist potency, via the recruitment of β-arrestin, independent of the subtype of G(α) protein activated. This assay is frequently used in drug discovery although little is known about the agonist pharma...
/tools-resources/publications-references/publications/reassessment-of-the-pharmacology-of-sphingosine-1
2/27/2013 10:11:10 PM
Surrogate readouts of G-protein-coupled receptor signaling pathways using highly engineered systems are often employed in the drug discovery process. However, accumulating data have demonstrated the importance of selecting relevant biological activity rather than technicall...
/tools-resources/publications-references/publications/predictability-of-peripheral-lymphocyte-reduction
9/14/2015 6:12:05 PM