This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected...
/target-data-sheets/gpcr/ebi2
2/12/2015 9:43:47 PM
/products/cell-line/ebi2-total-gpcr-internalization-u2os-cel-93-0910c3
/products/assay/ebi2-cho-k1-β-arrestin-gpcr-assay-93-0437e2acp21m
/products/assay/ebi2-cho-k1-β-arrestin-gpcr-assay-93-0437e2acp21l
/products/cell-line/cho-k1-ebi2-β-arrestin-cell-line-93-0437c2a
/products/cell-line/cho-k1-ebi2-gi-cell-line-95-0172c2
The Epstein-Barr virus induced gene 2 (EBI2) was recently identified as the first oxysterol-activated 7TM receptor. EBI2 is essential for B cell trafficking within lymphoid tissues and thus the humoral immune response in general. Here we characterize the antagonism of the n...
/tools-resources/publications-references/publications/small-molecule-antagonism-of-oxysterol-induced-eps
8/18/2015 4:20:03 PM
Oxysterols have recently been identified as natural ligands for a G protein-coupled receptor called EBI2 (aka GPR183) ( Nature 2011 , 475 , 524 ; 519 ). EBI2 is highly expressed in immune cells ( J. Biol. Chem. 2006 , 281 , 13199 ), and its activation has been shown to be c...
/tools-resources/publications-references/publications/identification-and-characterization-of-small-molec
8/18/2015 3:32:11 PM
Oxysterols are oxygenated cholesterol derivates that are emerging as a physiologically important group of molecules. Although they regulate a range of cellular processes, only few oxysterol-binding effector proteins have been identified, and the knowledge of their binding m...
/tools-resources/publications-references/publications/molecular-characterization-of-oxysterol-binding-to
8/18/2015 3:43:55 PM