ONC201, founding member of the imipridone class of compounds, has demonstrated evidence of tumor shrinkage along with exceptional safety in recurrent glioblastoma patients. In this study, we identified and characterized a previously unknown binding target of ONC201.
/tools-resources/document-resource-library/documents/dot-2017-differentiated-receptor-pharmacology-of-imipridone-onc201-the-first-drd2-antagonist-in-c
9/22/2017 6:46:54 PM
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism...
/target-data-sheets/kinase/ankk1
2/12/2015 9:46:14 PM
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene...
/target-data-sheets/gpcr/drd2l
2/12/2015 9:43:45 PM
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene...
/target-data-sheets/gpcr/drd2s
2/12/2015 9:43:46 PM
/products/membrane-preps/hts039m
/products/cell-line/cho-k1-drd2l-(long-isoform)-β-arrestin-c-93-0579c2
/products/cell-line/cho-k1-drd2l-(long-isoform)-gi-cell-line-95-0125c2
/products/cell-line/cho-k1-drd2s-(short-isoform)-β-arrestin-93-0351c2
/products/assay/drd2l-(long-isoform)-cho-k1-β-arrest-93-0579e2cp2m
/products/assay/drd2l-(long-isoform)-cho-k1-β-arrest-93-0579e2cp2l
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