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Cytotoxic T-lymphocyte protein 4 (CTLA4)

/target-data-sheets/checkpoint/ctla4 6/1/2016 6:22:33 AM
PathHunter® Jurkat CTLA4 Signaling Cell Line

/products/cell-line/jurkat-ctla4-signaling-cell-line-93-1094c19
TXK tyrosine kinase (TXK)
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell r...
/target-data-sheets/kinase/txk 2/12/2015 9:48:34 PM
PathHunter® U2OS CD86 Ligand Cell Line

/products/cell-line/u2os-cd86-ligand-cell-line-93-1093c3
Anti-CTLA4 Antibody [14D3]

/products/reagent/anti-ctla4-antibody-14d3-92-1319
Checkpoint Receptors
Applications Assay Principle Assay Highlights Advantages of Checkpoint Assays PathHunter checkpoint assays are MOA-reflective assays for quantifying a functional response as a result of direct ligand binding to its checkpoint receptor.  These cell-based assays enable rapid s...
/targets/checkpoint-assays 4/29/2020 4:06:29 PM
[PEGS 2017] Novel, Improved Cell-Based Assays to Enable Immunotherapy Drug Development for Checkpoint Receptors
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immunostimulatory checkpoint receptors have pr...
/tools-resources/document-resource-library/documents/pegs-2017-novel,-improved-cell-based-assays-to-enable-immunotherapy-drug-development-for-checkpoin 4/28/2017 9:04:39 PM
[2016 PEGS Conference] Novel, Improved Cell-based Assays to Enable Immunotherapy Drug Development for Checkpoint Receptors
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immunostimulatory checkpoint receptors have pro...
/tools-resources/document-resource-library/documents/2016-pegs-conference-novel-improved-cell-based-ass 4/14/2016 9:41:47 PM
[Advances in Drug Discovery 2017] Novel, Improved Cell-Based Assays to Enable Immunotherapy Drug Development for Checkpoint Receptors
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immunostimulatory checkpoint receptors have proved...
/tools-resources/document-resource-library/documents/advances-in-drug-discovery-2017-novel,-improved-cell-based-assays-to-enable-immunotherapy-drug-dev 3/2/2017 10:51:12 PM
[BEBPA USA 2017] Novel, Improved Cell-Based Assays to Enable Immunotherapy Drug Development for Checkpoint Receptors
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immunostimulatory checkpoint receptors have pr...
/tools-resources/document-resource-library/documents/bebpa-usa-2017-novel,-improved-cell-based-assays-to-enable-immunotherapy-drug-development-for-chec 3/7/2017 9:35:33 PM
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