CHIR 99021 (CT99021)

/products/reagent/chir-99021-(ct99021)-92-1116

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists.

A series of chiral pyridazin-3(2H)-ones was synthesized, separated as pure enantiomers, and evaluated for N-formyl peptide receptor (FPR) agonist activity. Characterization of the purified enantiomers using combined chiral HPLC and chiroptical studies (circular dichroism, a...

/tools-resources/publications-references/publications/synthesis-enantioresolution-and-activity-profile-o 9/11/2015 5:04:27 PM

Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).

Here, we examine the significance that stereochemistry plays within the clinically relevant Janus kinase 3 (Jak3) inhibitor 1 (CP-690,550). A synthesis of all four enantiopure stereoisomers of the drug was carried out and an examination of each compound revealed that only the ...

/tools-resources/publications-references/publications/examining-the-chirality-conformation-and-selective 10/3/2012 5:51:35 PM

Reference Compound Data

Contact a Specialist Reference Data & Interaction Maps for Kinase Inhibitor Compounds KINOME scan ® data has been widely published and referenced in leading publications and support many landmark kinase inhibitors papers.  These data represent among the most extensive co...

/services/drug-discovery-development-services/kinase-profiling/reference-compound-data 9/27/2012 3:39:09 PM