/products/cell-line/jurkat-cd28-signaling-cell-line-93-1126c19
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked t...
/tools-resources/publications-references/publications/the-engineered-cd80-variant-fusion-therapeutic-dav
5/24/2022 11:38:03 PM
Chimeric antigen receptor (CAR)-T cells, which are engineered to recognize target cell surface antigens expressed on tumor cells, have shown promise to affect complete remission in patients with B-cell malignancies. However, applying this approach to target solid tumors has r...
/tools-resources/document-resource-library/documents/slas-2017-car-t-cell-screening-in-tumor-spheroids-using-corning-spheroid-microplates
2/9/2017 4:53:25 PM
The PathHunter Checkpoint Receptor Signaling Assay is a simple, highly specific assay to enable discovery and development of small molecule and biologic drugs targeting immune checkpoint receptors, belonging to the Immunoglobulin Superfamily (IgSF), such as PD-1, CD28 and ICO...
/tools-resources/document-resource-library/documents/user-manual-pathhunter®-checkpoint-signaling-ass
12/4/2015 4:41:54 PM
Applications Assay Principle Assay Highlights Advantages of Checkpoint Assays PathHunter checkpoint assays are MOA-reflective assays for quantifying a functional response as a result of direct ligand binding to its checkpoint receptor. These cell-based assays enable rapid s...
/targets/checkpoint-assays
4/29/2020 4:06:29 PM
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immuno-stimulatory checkpoint receptors have prove...
/tools-resources/document-resource-library/documents/dot-2017-novel,-improved-cell-based-assays-to-enable-immunotherapy-drug-development-for-checkpoint
9/22/2017 6:37:39 PM
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immuno-stimulatory checkpoint receptors have prove...
/tools-resources/document-resource-library/documents/elrig-2017-novel,-improved-cell-based-assays-to-enable-immunotherapy-drug-development-for-checkpoi
9/26/2017 11:24:43 PM
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immuno-stimulatory checkpoint receptors have prov...
/tools-resources/document-resource-library/documents/bebpa-2017-checkpoint-receptor-poster
9/27/2017 5:50:09 PM
PGD2, produced by mast cells, has been detected in high concentrations at sites of allergic inflammation. It can stimulate vascular and other inflammatory responses by interaction with D prostanoid receptor (DP) and chemoattractant receptor-like molecule expressed on Th2 cells...
/tools-resources/publications-references/publications/prostaglandin-d2-causes-preferential-induction-of
10/3/2012 5:51:07 PM