/products/reagent/recombinant-human-cd27-ligand-(tnfsf7)-92-1362
/products/cell-line/hek-293-cd27-nf-kb signaling-pathway-rep-93-1166c1
Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.PDCD1LG2 has also been designated as CD273 and has been speculated to play a major role in suppressing the immune system, with possible roles in cancer-in...
/target-data-sheets/checkpoint/pd-l2
12/4/2015 11:45:56 PM
PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechani...
/target-data-sheets/checkpoint/pd-1
12/8/2015 11:24:30 PM
Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis...
/target-data-sheets/checkpoint/pd-l1
12/4/2015 11:45:56 PM
Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis...
/target-data-sheets/checkpoint/pd-l1-pd-l1
2/7/2018 5:46:14 PM
Applications Assay Principles Assay Highlights Assay Highlights Greater Understanding – Assess both receptor-upstream and -downstream responses for a comprehensive understanding of the drug molecule’s MOA Versatile – Suitable for screening agonists or antagonists, and ...
/products-applications/signaling-pathway-reporters
6/3/2020 11:01:02 PM
/products/reagent/anti-pd1-antibody-nat105-92-1290
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immunostimulatory checkpoint receptors have pr...
/tools-resources/document-resource-library/documents/pegs-2017-novel,-improved-cell-based-assays-to-enable-immunotherapy-drug-development-for-checkpoin
4/28/2017 9:04:39 PM
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immunostimulatory checkpoint receptors have pr...
/tools-resources/document-resource-library/documents/bebpa-usa-2017-novel,-improved-cell-based-assays-to-enable-immunotherapy-drug-development-for-chec
3/7/2017 9:35:33 PM
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