This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation ...
2/12/2015 9:43:30 PM
BACKGROUND AND PURPOSE: A conserved amino acid within a protein family indicates a significance of the residue. In the centre of transmembrane helix (TM)-5, position V:13/5.47, an aromatic amino acid is conserved among class A 7TM receptors. However, in 37% of chemoki...
8/13/2015 4:52:17 PM
In addition to the 7 transmembrane receptor (7TM)-conserved disulfide bridge between transmembrane (TM) helix 3 and extracellular loop (ECL)-2, chemokine receptors (CCR) contain a disulfide bridge between the N terminus and what previously was believed to be ECL-3. Recent c...
8/13/2015 4:01:57 PM
Features & Benefits DiscoverX provides the largest portfolio of GPCR assays and now for the first time, a unique service that utilizes state of the art tools developed by Professor Terry Kenakin* for characterization of ligand bias. With the appropriate β-Arrestin, Internali...
8/12/2015 9:32:10 PM
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