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Recombinant Murine CCL22

/products/reagent/recombinant-murine-ccl22-92-1016
Recombinant Human CCL22

/products/reagent/recombinant-human-ccl22-92-1006
Surrogate antibodies that specifically bind and neutralize CCL17 but not CCL22.
The chemokines CCL17 (TARC) and CCL22 (MDC) function through the same receptor, CCR4, but have been proposed to differentially affect the immune response. To better understand the role of the individual ligands, a panel of rat anti-mouse CCL17 surrogate antibodies was gener...
/tools-resources/publications-references/publications/surrogate-antibodies-that-specifically-bind-and-ne 8/13/2015 4:08:56 PM
Chemokine (C-C motif) receptor 4 (mCCR4)
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock...
/target-data-sheets/gpcr/mccr4 2/12/2015 9:44:53 PM
Engagement of two distinct binding domains on CCL17 Is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung.
CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CCR4-mediated recruitment ...
/tools-resources/publications-references/publications/engagement-of-two-distinct-binding-domains-on-ccl1 8/13/2015 4:15:18 PM
PathHunter® eXpress CCR4 CHO-K1 β-Arrestin GPCR Assay

/products/assay/ccr4-cho-k1-β-arrestin-gpcr-assay-93-0193e2cp0m
PathHunter® eXpress CCR4 CHO-K1 β-Arrestin GPCR Assay

/products/assay/ccr4-cho-k1-β-arrestin-gpcr-assay-93-0193e2cp0l
PathHunter® eXpress mCCR4 CHO-K1 β-Arrestin GPCR Assay

/products/assay/mccr4-cho-k1-β-arrestin-gpcr-assay-93-0515e2mcp0m
PathHunter® eXpress mCCR4 CHO-K1 β-Arrestin GPCR Assay

/products/assay/mccr4-cho-k1-β-arrestin-gpcr-assay-93-0515e2mcp0l
PathHunter® CHO-K1 CCR4 β-Arrestin Cell Line

/products/cell-line/cho-k1-ccr4-β-arrestin-cell-line-93-0193c2
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