This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf
2/12/2015 9:46:19 PM
VRAF murine sarcoma viral oncogene homologue B1 (BRAF) kinase has proved to be a promising target for the development of therapeutics for the treatment of a variety of human cancers. Here, we report the first example of a successful application of the structure-based virtual s...
/tools-resources/publications-references/publications/identification-of-novel-braf-kinase-inhibitors-wit
10/3/2012 5:51:27 PM
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf(v600e)
2/12/2015 9:46:19 PM
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good phar...
/tools-resources/publications-references/publications/4-quinazolinyloxy-diaryl-ureas-as-novel-brafv600e
10/3/2012 5:51:28 PM
Contact a Specialist Reference Data & Interaction Maps for Kinase Inhibitor Compounds KINOME scan ® data has been widely published and referenced in leading publications and support many landmark kinase inhibitors papers. These data represent among the most extensive co...
/services/drug-discovery-development-services/kinase-profiling/reference-compound-data
9/27/2012 3:39:09 PM
KINOME scan Gene Symbol td:first-child { background-color:#FFFFCC; } KINOMEscan Gene Symbol Entrez Gene Symbol Accession Number AAK1 AAK1 NP_055726.3 ABL1(E255K)-phosphorylated ABL1 NP_005148.2 ABL1(F317I)...
/services/drug-discovery-development-services/kinase-profiling/kinomescan/gene-symbol
3/4/2016 8:11:57 PM
Find a Product "Cysteinome" Assay Portfolio - potential targets for the rational development of irreversible inhibitors In a recent publication ( Liu Q., et.al . 2013 ) they identify almost 200 kinases that contain a reactive nucleophilic cysteine residue near the ATP bin...
/targets/kinase-target-biology/cysteine-kinases
10/10/2014 5:14:34 PM
Mutant Kinase Reference Guide Understanding Compound Selectivity in Mutant Kinases Protein kinases play an integral role as mediators of multiple signal transduction pathways and are responsible for the modulation of essential cellular functions including cell proliferatio...
/tools-resources/document-resource-library/mutant-kinase-reference-guide
10/9/2012 10:09:17 PM