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v-raf murine sarcoma viral oncogene homolog B1 (BRAF)
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf 2/12/2015 9:46:19 PM
Identification of novel BRAF kinase inhibitors with structure-based virtual screening.
VRAF murine sarcoma viral oncogene homologue B1 (BRAF) kinase has proved to be a promising target for the development of therapeutics for the treatment of a variety of human cancers. Here, we report the first example of a successful application of the structure-based virtual s...
/tools-resources/publications-references/publications/identification-of-novel-braf-kinase-inhibitors-wit 10/3/2012 5:51:27 PM
v-raf murine sarcoma viral oncogene homolog B1 (BRAF(V600E))
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf(v600e) 2/12/2015 9:46:19 PM
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good phar...
/tools-resources/publications-references/publications/4-quinazolinyloxy-diaryl-ureas-as-novel-brafv600e 10/3/2012 5:51:28 PM
Reference Compound Data
Contact a Specialist Reference Data & Interaction Maps for Kinase Inhibitor Compounds KINOME scan ® data has been widely published and referenced in leading publications and support many landmark kinase inhibitors papers.  These data represent among the most extensive co...
/services/drug-discovery-development-services/kinase-profiling/reference-compound-data 9/27/2012 3:39:09 PM
Gene Symbol
KINOME scan Gene Symbol td:first-child { background-color:#FFFFCC; } KINOMEscan Gene Symbol Entrez Gene Symbol Accession Number AAK1 AAK1 NP_055726.3 ABL1(E255K)-phosphorylated ABL1 NP_005148.2 ABL1(F317I)...
/services/drug-discovery-development-services/kinase-profiling/kinomescan/gene-symbol 3/4/2016 8:11:57 PM
Available Cysteine Kinases
Find a Product "Cysteinome" Assay Portfolio - potential targets for the rational development of irreversible inhibitors In a recent publication ( Liu Q., et.al . 2013 ) they identify almost 200 kinases that contain a reactive nucleophilic cysteine residue near the ATP bin...
/targets/kinase-target-biology/cysteine-kinases 10/10/2014 5:14:34 PM
Mutant Kinase Reference Guide
Mutant Kinase Reference Guide Understanding Compound Selectivity in Mutant Kinases Protein kinases play an integral role as mediators of multiple signal transduction pathways and are responsible for the modulation of essential cellular functions including cell proliferatio...
/tools-resources/document-resource-library/mutant-kinase-reference-guide 10/9/2012 10:09:17 PM
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