The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion ...
/target-data-sheets/kinase/abl1(t315i)-nonphosphorylated
2/12/2015 9:46:07 PM
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion ...
/target-data-sheets/kinase/abl1(t315i)-phosphorylated
2/12/2015 9:46:07 PM
/products/proteins/14-522
/products/proteins/14-522m
A series of alkyne-containing type II inhibitors with potent inhibitory activity of T315I Bcr-Abl has been identified. The most active compound 4 exhibits an EC(50) of less than 1 nM against wild-type Bcr-Abl and an EC(50) of 10 nM against T315I mutant but is broadly active ag...
/tools-resources/publications-references/publications/broad-spectrum-alkynyl-inhibitors-of-t315i-bcr-abl
10/3/2012 5:51:31 PM
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion ...
/target-data-sheets/kinase/abl1
10/10/2016 6:05:51 PM
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion ...
/target-data-sheets/kinase/abl1(e255k)-phosphorylated
2/12/2015 9:46:04 PM
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion ...
/target-data-sheets/kinase/abl1(f317i)-nonphosphorylated
2/12/2015 9:46:04 PM
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion ...
/target-data-sheets/kinase/abl1(f317i)-phosphorylated
2/12/2015 9:46:05 PM
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion ...
/target-data-sheets/kinase/abl1(f317l)-nonphosphorylated
2/12/2015 9:46:05 PM
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