Publications
Showing 1–12 of 33 results
Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a…
Read MoreType 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a…
Read MorePhosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are emerging as attractive therapeutic targets in diseases, such as cancer, immunological disorders, and neurodegeneration, owing…
Read MoreA series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for…
Read MoreBrain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and…
Read MoreSystemic therapy of advanced hepatocellular carcinoma (HCC) with the small molecule multi-kinase inhibitor sorafenib is associated with large inter-individual pharmacokinetic…
Read MoreCurrent therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against…
Read MoreStrong genetic data link the Tyrosine kinase receptor B (TrkB) and its major endogenous ligand brain-derived neurotrophic factor (BDNF) to…
Read MoreG-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides,…
Read MoreOwing to their central role in regulating cell signaling pathways, the phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are attractive therapeutic targets in…
Read MoreIn this study, we describe the evaluation of a cell-based protein stability assay using β-galactosidase fragment complementation technology performed in…
Read MoreFYVE-type zinc finger-containing phosphoinositide kinase (PIKfyve) catalyzes the formation of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) from phosphatidylinositol 3-phosphate (PI(3)P).
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