Blogs & Articles

Showing 1–12 of 30 results

Blogs & Articles Webinar Recap: Ion Channel Drug Discovery – Recent Advances in Novel Non-Opioid Pain Research

Ion channels represent a key target class for therapeutics to treat human disease. The prevalence of debilitating pain disorders and…

Blogs & Articles Advancing Therapeutics Targeting Cytokines

As key mediators of immune responses, cytokines have emerged as major drug targets for inflammatory and autoimmune diseases. A significant…

Blogs & Articles Functional Assays for Screening, Characterization, & Clinical Development of Agonistic Antibodies for Immunotherapy & Autoimmune Diseases

Agonistic Antibodies and the Role of Checkpoint Receptors in Immune Function

Blogs & Articles Developing A Simple Antibody Dependent Cell-Mediated Cytotoxicity Assay to Measure Target Cell Death

Most therapeutic antibodies have a Fab’ region that binds the antigen, and an Fc region which binds to and activates…

Blogs & Articles Ligand Bias: Increasing specificity and Reducing Side Effects of Drug Compounds

Ligand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is…

Blogs & Articles Why Study GPCR Arrestin Recruitment?

Arrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation of…

Blogs & Articles Ideal Methods to Study Cellular Transport Of Membrane Proteins

Translocation and Trafficking of Membrane Proteins

Blogs & Articles Four Reasons Why You Should Measure and Quantify Signaling bias in Your Molecules

Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure…

Blogs & Articles Critical Needs in Cellular Target Engagement

The development of new medicines for treating diseases and new chemical probes for elucidating biological function continues to rely on…

Blogs & Articles The Mast Cell Receptor Mrgx2 and Drug-induced Anaphylaxis

Presenting a compelling narrative on the pharmacological characterization of the MRGX2 gene. Dr. Brown emphasized the receptor’s importance as a…

Blogs & Articles Eliminating Donor Variability in ADCC Assays – Implementation in QC Lot Release

Class I therapeutic antibodies achieve their clinical efficacy by binding to their target antigen and through Fragment crystallisable region (Fc)…

Blogs & Articles Do-It-Yourself: Benefits and Challenges of Creating Your Own Cell-Based Assays

Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or drugs…