Blogs & Articles

Showing 1–12 of 28 results

Blogs & Articles Functional Assays for Screening, Characterization, & Clinical Development of Agonistic Antibodies for Immunotherapy & Autoimmune Diseases

Agonistic Antibodies and the Role of Checkpoint Receptors in Immune Function

Blogs & Articles Developing A Simple Antibody Dependent Cell-Mediated Cytotoxicity Assay to Measure Target Cell Death

Most therapeutic antibodies have a Fab’ region that binds the antigen, and an Fc region which binds to and activates…

Blogs & Articles Ligand Bias: Increasing specificity and Reducing Side Effects of Drug Compounds

Ligand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is…

Blogs & Articles Why Study GPCR Arrestin Recruitment?

Arrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation of…

Blogs & Articles Ideal Methods to Study Cellular Transport Of Membrane Proteins

Translocation and Trafficking of Membrane Proteins

Blogs & Articles Four Reasons Why You Should Measure and Quantify Signaling bias in Your Molecules

Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure…

Blogs & Articles Critical Needs in Cellular Target Engagement

The development of new medicines for treating diseases and new chemical probes for elucidating biological function continues to rely on…

Blogs & Articles The Mast Cell Receptor Mrgx2 and Drug-induced Anaphylaxis

Presenting a compelling narrative on the pharmacological characterization of the MRGX2 gene. Dr. Brown emphasized the receptor’s importance as a…

Blogs & Articles Comparison of InCELL Hunter™ vs InCELL Pulse™ for Analyzing Compound-Target Engagement

Whether you’re looking to screen a library of drug candidates for binding to a particular target protein, checking drug cell…

Blogs & Articles Do-It-Yourself: Benefits and Challenges of Creating Your Own Cell-Based Assays

Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or drugs…

Blogs & Articles Accelerating Biologics Development Programs With Phase-Appropriate Ready-To-Use Potency Bioassays

Biological activity of a biotherapeutic is a Critical Quality Attribute (CQA), which needs to be accurately measured by an appropriate…

Blogs & Articles Eliminating Donor Variability in ADCC Assays – Implementation in QC Lot Release

Class I therapeutic antibodies achieve their clinical efficacy by binding to their target antigen and through Fragment crystallisable region (Fc)…