Kinase Solutions

High-Quality, Cellular and Biochemical Kinase Assays with Full Human Kinome Coverage

DiscoverX offers accurate, reproducible kinase assays with complete human kinome coverage so you can always find a solution for your kinase target. Our kinase profiling service, KINOMEscan®,includes an industry-leading set of nearly 500 assays, allowing rapid and efficient determination of kinome-wide potency and selectivity of compounds. By integrating EFC technology with deep kinase knowledge and cell-based assays expertise, we offer a growing menu of cellular, functional assays to detect activated kinases along with binding assays for compound-target engagement. When used alone or in combination, these robust assay platforms can be used at all stages of drug discovery and are ideal for identifying highly potent and selective kinase inhibitors.

 

Create Your Own RTK Functional, Cell-Based Assays

Watch this 30-minute webinar to learn how to make your own receptor tyrosine kinase (RTK) cell-based assays to analyze RTK function, dimerization, and translocation as well as screening of RTK therapeutics. Cytokine receptors and cytosolic (CTK) cell-based assays are discussed.

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Expedite Lead Optimization with Kinase Screening Services


KINOMEscan Kinase Profiling Services

The leading selectivity profiling service for kinase inhibitor drug discovery. Leveraging both our panel of over 480 kinase assays and our kinase inhibitor drug discovery expertise, KINOMEscan provides investigators the benefit of kinome-wide profiling, the flexibility to create personalized screening solutions, and the knowledge to support and inform decision making throughout the kinase drug development continuum.

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Robust, Cellular Functional Receptor Kinase Assays


PathHunter® Cell-Based Assays for RTKs and CTKs

Fully optimized, target-validated cell-based kinase assays allow you to study kinase activation, dimerization, receptor internalization, SH2-recruitment, and screen for novel kinase inhibitors of both receptor tyrosine kinase (RTK) and cytosolic tryosine kinase (CTK). Our growing panel of tyrosine kinase assays are available as cell lines, assay ready kits, build-your-own assay tools, or services.

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Universal Compound-Target Engagement Cell-Based Assays


InCELL Cell-Based Assays for Intracellular Kinases

InCELL Hunter and InCELL Pulse cellular compound-target engagement assays provide the ability to create your own assays for intracellular kinases as well as confirm compound cell entry, target binding, screen inhibitors, measure cellular EC50 values, and rank compounds--all in the native cellular environment

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Simple Fluorescent Assay for Kinase Profiling and Screening


ADP Accumulation Assay

The ADP Accumulation Assay is a generic, antibody-free, homogeneous assay platform that detects kinase activity by monitoring ATP depletion. Reliably measure phosphotransferase-mediated production of ADP, providing a positive signal that increases in direct proportion to ADP accumulation.


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Webinars

Create Your Own Cell-Based Assays to Study Receptor Tyrosine Kinase Function  Watch Webinar
KINOMEscan Kinase Broad Profiling and Phenotypic Screening  Watch Webinars
InCELL Cellular Compound Target Engagement  Watch Webinars
 

Blog Articles

An Expanding Chemogenomic Toolbox Gives Kinome Research a Welcome and Much Needed Boost  Read Article
Do-It-Yourself: Benefits and Challenges of Creating Your Own Cell-Based Assays Read Article
The Key to Designing a Kinase Screening Project  Read Article
Critical Needs in Cellular Target Engagement  Read Article
Kinome-Wide Profiling of Existing Chemical Assets: A Powerful Strategy to Jump-Start New Drug Discovery Programs  Read Article
DiscoverX and the SGC Partner to Make an Annotated Collection of >600 Kinase Inhibitors Freely Available  Read Article
 

Brochures and Flyers

KINOMEscan KdELECT® Kinase Screening and Profiling  Download Flyer
InCELL Target Engagement Assays  Download Flyer
PathHunter Protein Translocation Assays  Download Flyer
PathHunter MAX Panel Screening and Profiling Services  Download Flyer
 

Resources

Kinase Targets  View List
Kinase Publications  View Publications
KINOMEscan Tools and Resources  Access Resources
InCELL Pulse Target Engagement Kinase Reference Set  Download Booklet
 

Custom Assay Development Services

Can't find your assay on the menu? We can develop it for you. Learn More
 

Technical Bulletins

Updated Cell Culture and Handling Procedure. Read Protocol