Cell-Based Bioassays for Biologics
Ready-to-Use Cell-Based Assays for Comparability and QC Lot Release Testing
Pharmaceutical companies are developing an increasing number of biologics, biosimilars and biobetters, thereby creating a need for MOA-reflective cell-based assays that can support multiple stages of the biopharmaceutical development pipeline. DiscoverX offers the largest menu of “
Thaw & Use” Bioassay kits that have been qualified with marketed biologic drugs or reference standards. Bioassay kits are also available as target-specific cell-based bioassays that are easy to implement in any lab from development to QC/Lot release.
Qualified Bioassays
Thaw-and-use bioassay kits qualified with marketed biologic drugs.
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Target-Based Bioassays
Rapid, robust, and reproducible target-based bioassay kits.
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Custom Bioassays
Request early access to bioassay kits that are currently being qualified.
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Available Targets
Chose from over 750 targets to develop bioassays for your biologics.
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Bioassay Formats
PathHunter® Bioassays are ideal for determining drug potency and stability using a simple and rapid, mix & read protocol that reflects the drug’s clinical mechanism of action. The Bioassays can be used to detect neutralizing anti-drug antibodies (ADAs) or NAbs in patient serum samples, with high sensitivity and reproducibility.
Potency and Stability
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Neutralizing Antibodies
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Four Applications of PathHunter Technology for Biologics Development
DiscoverX has exploited the versatile features of enzyme fragment complementation (EFC) technology to create cell-based assays for a vast number of proteins. PathHunter assays are designed using two inactive fragments of β-galactosidase (β-gal), which combine to create an active enzyme. Click on the images below to learn more about solutions for the specific applications you are interested in.