ZAK, active

N-terminal GST-tagged, recombinant, human ZAK full length expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.

Catalog #: 15-015


Biological Information
Background Information:
ZAK is a member of the MAPKKK family of signal transduction molecules and is a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Product Type:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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15-015x Datasheet

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