TSSK3, active

Background Information:

TSSK3 (Testis-specific serine/threonine-protein kinase 3) is a serine/threonine protein kinase that is primarily expressed in the testis, where it plays a role in the regulation of spermatogenesis. TSSK3 has been shown to be involved in the regulation of sperm motility and morphology, and alterations in TSSK3 expression and activity have been linked to male infertility. Research has suggested that TSSK3 may also play a role in cancer. TSSK3 has been shown to be overexpressed in several types of cancer, including breast cancer and prostate cancer, and high levels of TSSK3 expression have been associated with poor prognosis. Additionally, TSSK3 has been suggested as a potential therapeutic target in cancer, and efforts to develop small-molecule inhibitors of the kinase are underway.

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

TSSK3

Protein Aliases:

TSSK-3|Testis-specific kinase 3|Serine/threonine-protein kinase 22C

Accession Number:

NM_052841.2

UniProt Number:

Q96PN8

Gene Name:

TSSK3

Gene ID:

81629

Gene Aliases:

SPOGA3

Target Species:

Human