| Biological Information | |
|---|---|
| Background Information: | TAOK2 (TAO Kinase 2) is a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. TAO2 is involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. In response to DNA damage, TAO2 is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.
GenBank NM_016151 |
| Target Class: | Kinase |
| Accession Number: | NM_004783.2; NM_016151.2 |
| Target Name: | TAO2 |
| Target Aliases: | TAOK2, TAO1, TAO2, PSK, PSK1, MAP3K17, KIAA0881, hKFC-C, PSK-1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
TAO2, active
N-terminal 6His-tagged recombinant, TAO2. TAO2 is a mitogen-activated protein Kinase kinase kinase (MAP3K) that doubly phosphorylates and activates the MAP Kinase kinases (MAP2Ks) MEK3 and MEK6.
Datasheets
14-736x Datasheet
View Document