Biological Information

Background Information:

SPRINTer™ Endogenous Protein Turnover Biosensor Cell Lines are stable clonal cell lines used for monitoring drug-induced protein turnover of a specific endogenous target. Genome engineering or editing techniques, such as CRISPR/Cas9, are used to introduce a small tag into the endogenous locus of interest. This allows for the quantitation of changes in target protein levels when cells are treated with therapeutic agents such as targeted protein degraders.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

B-Raf

Protein Aliases:

Proto-oncogene B-Raf|p94|v-Raf murine sarcoma viral oncogene homolog B1

Accession Number:

NP_00161187

UniProt Number:

P15056

Gene Name:

BRAF

Gene ID:

673

Gene Aliases:

BRAF1

Target Species:

Human

Cell Background:

A375

Usage

Product Type:

Stable Cell Lines

Application:

Targeted Protein Degradation

Storage Conditions:

Short term (24 h): Store in vapor phase of liquid nitrogen.

Usage disclaimer:

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Assay Information

Assay Type:

Cell Based

Assay Measures:

Targeted Protein Degradation (TPD)

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology

Additional Information

Brand:

SPRINTer™