sirtuin 2

Background Information:

Sirtuin 2 (SIRT2) is a member of the Sirtuin family of NAD+-dependent histone deacetylases (HDACs). These proteins play a key role in epigenetic regulation, which refers to changes in gene expression that are not due to alterations in DNA sequence. SIRT2 is involved in regulating many cellular processes, including cell division, DNA repair, and metabolism. One of the primary functions of SIRT2 is the deacetylation of histones, which are proteins that help package DNA into the compact structure of chromatin.
SIRT2 has been implicated in several diseases, including cancer, neurodegeneration, and metabolic disorders. For example, in cancer, SIRT2 has been shown to have both tumor-promoting and tumor-suppressing effects, depending on the context. In neurodegenerative diseases such as Alzheimer's and Parkinson's, SIRT2 appears to play a role in the aggregation of misfolded proteins.

Target Class:

Epigenetic

Family:

Histone Deacetylase (HDAC)

Sub Family:

Eraser

Protein Name:

Sirtuin 2

Accession Number:

NM_012237.4

UniProt Number:

Q8IXJ6

Gene Name:

SIRT2

Gene ID:

22933

Target Species:

Human