SETD7

Background Information:

SETD7 (SET domain-containing protein 7) is a lysine methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the lysine 4 residue of histone H3 (H3K4), leading to the formation of monomethylated H3K4. SETD7 is a member of the SET domain-containing protein family and is the only known enzyme that specifically methylates H3K4 in a monomethylated form.
SETD7 is dysregulated in various types of cancer, including breast cancer, prostate cancer, and hepatocellular carcinoma. Its dysregulation has been linked to aberrant gene expression, genome instability, and defects in DNA repair, which can contribute to the development and progression of cancer.
SETD7 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve insulin sensitivity in preclinical models of cancer and diabetes, respectively.

Target Class:

Epigenetic

Family:

Histone Methyltransferase (HMT)

Sub Family:

Writer

Protein Name:

SETD7 / SET9

Accession Number:

NM_030648.4

UniProt Number:

Q8WTS6

Gene Name:

SETD7

Gene ID:

80854

Gene Aliases:

KIAA1717|SET7|SET7/9|Set9|KMT7

Target Species:

Human