Ready-to-Assay GPR103/Peptide P518 Receptor Frozen Cells

Background Information:

The Ready-to-Assay GPR103/Peptide P518 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. QRFP neuropeptides) based activation of QRFPR GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress QRFPR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of QRFPR , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

QRFP

Sub Family:

Class A

Protein Name:

GPR103 (QRFP)

Protein Aliases:

peptide P518 receptor

Accession Number:

NM_198179

UniProt Number:

Q96P65

Gene Name:

QRFPR

Gene ID:

84109

Target Species:

Human

Cell Background:

Chem-1