Ready-to-Assay CCR4 Chemokine Receptor Frozen Cells

Background Information:

The Ready-to-Assay CCR4 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. MIP, RANTES) based activation of CCR4 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress CCR4 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CCR4 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CCR4

Protein Aliases:

CC-CKR-4|CCR-4|CCR4|K5-5|CD antigen CD194

Accession Number:

X85740

UniProt Number:

P51679

Gene Name:

CCR4

Gene ID:

1233

Gene Aliases:

CC-CKR-4|CMKBR4|CKR4|k5-5|ChemR13|CD194

Target Species:

Human

Cell Background:

Chem-5