| Biological Information | |
|---|---|
| Background Information: | Proline-rich tyrosine kinase 2 (PTK2B) (also called CAKb for cell adhesion kinase b, RAFTK for related adhesion focal tyrosine kinase, or CADTK for calcium-dependent tyrosine kinase) is a non-receptor tyrosine kinase structurally related to focal adhesion kinase (FAK). PTK2B interacts with Src family kinases and focal adhesion proteins such as p130Crk-associated substrate (p130Cas) and its homologue p105 human enhancer of filamentation 1 (HEF1). PTK2B is particularly enriched in pulmonary vascular endothelial cells and lung, a major organ site for tumor metastasis. Inhibitors of PTK2B may be useful in the treatment of lung cancer.
GenBank S80542 |
| Target Class: | Kinase |
| Family: | Cytosolic Tyrosine Kinase |
| Accession Number: | NM_004103.3; NM_173174.1; NM_173175.1; NM_173176.1 |
| Target Name: | PYK2 |
| Target Aliases: | PTK2BRAFTKFAK2PYK2FADK2PTKCADTKCAKBPKB |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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Pyk2, active
N-terminal 6His-tagged recombinant, human full length Pyk2.
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