PTPbeta, active

Background Information:

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. GenBank NM_002837.2

Target Class:

Phosphatase

Family:

RTP

Sub Family:

Protein Tyrosine

Protein Name:

PTPbeta

Accession Number:

NM_002837.2

UniProt Number:

P23467

Gene Name:

PTPRB

Gene ID:

5787

Target Species:

Human