PrecisION™ Recombinant hERG Potassium Ion Channel Membrane Preparation

Background Information:

The PrecisION™ hERG membrane prep is a crude membrane prep with high levels of hERG for use in studying binding affinity of drug candidates (small molecules or biologics) targeting ion channels. This membrane prep enables assessment of ligand binding affinity via detection of levels of radioactivity. It is derived from our proprietary stable recombinant cell lines to ensure high levels of hERG surface expression. PrecisION™ membrane preps can be used to screen for ligand binding affinities at hERG using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1mL of 2mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression.

Target Class:

Ion Channel

Family:

Potassium

Sub Family:

Voltage-Gated

Protein Name:

hERG

Protein Aliases:

Ether-a-go-go-related gene potassium channel 1|ERG-1|Eag-related protein 1|Ether-a-go-go-related protein 1|H-ERG|hERG-1|hERG1|Voltage-gated potassium channel subunit Kv11.1

Accession Number:

U04270

UniProt Number:

Q12809

Gene Name:

KCNH2

Gene ID:

3757

Gene Aliases:

Kv11.1|HERG|erg1

Target Species:

Human

Cell Background:

HEK293