Biological Information
Background Information:
The PrecisION™ hnAChR α3/β4 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying nAChR α3/β4 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses nAChR α3/β4 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques.
This stable engineered cell line is provided as two vials of cryopreserved cells.
Target Class:
Ion Channel
Family:
Acetylcholine (Nicotinic)
Sub Family:
Ligand-Gated
Protein Name:
nAChR
Protein Aliases:
acetylcholine receptor, nicotinic, alpha 3 (neuronal)
Accession Number:
M37981, NM_000750
UniProt Number:
P32297
Gene Name:
CHRNA3
Gene ID:
1136
Target Species:
Human
Cell Background:
HEK293
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
Electrophysiology
Detection Method:
Electrophysiology
Additional Information
Brand:
PrecisION™