| Biological Information | |
|---|---|
| Background Information: | Two serine/threonine protein kinase D isoforms (PKD1 and PKD2), belonging to the polycystin family, are involved in protein-protein and protein-carbohydrate adhesion. The two isoforms are known to interact, and also thought to be ion channel regulators. PKD2 (PKD4, APKD2) bears closest homology with PKCmicro; and PKCnu;. Stimuli that activate PKD2 include phorbol esters, gastrin, and classical and novel PKC family members. Defects in PKD (inhibition of function) is responsible for human autosomal dominant polycystic kidney disease (ADPKD) that causes progressive renal failure and may also lead to liver cysts.
GenBank NM_016457 |
| Target Class: | Kinase |
| Accession Number: | NM_001079880.1; NM_001079881.1; NM_001079882.1; NM_016457.4 |
| Target Name: | PKD2 |
| Target Aliases: | PRKD2, DKFZP586E0820, PKD2, nPKC-D2, HSPC187 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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PKD2, active
N-terminal 6His-tagged recombinant, human full length PKD2.
Datasheets
14-506x Datasheet
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