PKC iota, active

Background Information:

Protein kinase C, iota (PKCiota, PRKCI) is one of the major protein kinase C isoforms of a family of serine/threonine protein kinases. Breakdown of phosphatidylinositol leads to formation of diacylglycerol and inositol triphosphate, the former acting synergistically with Ca2+ to activate protein kinase C (PKC), resulting in translocation of the enzyme from cytosol to the membrane. Phosphorylation of proteins by PKC has been implicated as a pivotal regulatory element in signal transduction, cellular regulation, and with a high affinity to phorbol ester tumor promoters. GenBank NM_002740

Target Class:

Kinase

Family:

PKC

Sub Family:

Protein Ser/Thr

Protein Name:

PKCiota

Protein Aliases:

Atypical protein kinase C-lambda/iota|PRKC-lambda/iota|aPKC-lambda/iota|nPKC-iota

Accession Number:

NM_002740.5

UniProt Number:

P41743

Gene Name:

PRKCI

Gene ID:

5584

Gene Aliases:

PKCI|DXS1179E

Target Species:

Human