| Biological Information | |
|---|---|
| Background Information: | Protein kinase C, iota (PKCiota, PRKCI) is one of the major protein kinase C isoforms of a family of serine/threonine protein kinases. Breakdown of phosphatidylinositol leads to formation of diacylglycerol and inositol triphosphate, the former acting synergistically with Ca2+ to activate protein kinase C (PKC), resulting in translocation of the enzyme from cytosol to the membrane. Phosphorylation of proteins by PKC has been implicated as a pivotal regulatory element in signal transduction, cellular regulation, and with a high affinity to phorbol ester tumor promoters.
GenBank NM_002740 |
| Target Class: | Kinase |
| Accession Number: | NM_002740.5 |
| Target Name: | PKCι |
| Target Aliases: | PRKCI, DXS1179E, MGC26534, PRKC-lambda/iota, PKCI, aPKC-lambda/iota, nPKC-iota |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PKC iota, active
N-terminal 6His-tagged recombinant, human full length PKC iota PKC Lipid activator (Catalog # 20-133) is required for use.
Datasheets
14-505x Datasheet
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