PI3 Kinase (p120gamma)

Background Information:

PI3 Kinase (p120γ) belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. GenBank AF327656. The recombinant protein contains the amino acid substitution R459Q with respect to this accession number. This conflict is reported in GenBank XM_027912. The residue coordinates in the native sequence are given.

Target Class:

Kinase

Family:

PtdIns(4,5)P 3-Kinase

Sub Family:

Lipid

Protein Name:

PI3Kgamma

Protein Aliases:

PI3K-gamma|PI3Kgamma|PtdIns-3-kinase subunit gamma|Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|PtdIns-3-kinase subunit p110-gamma|p110gamma|Phosphoinositide-3-kinase catalytic gamma polypeptide|Serine/threonine protein kinase PIK3CG|p120-PI3K

Accession Number:

NM_002649.2

UniProt Number:

P48736

Gene Name:

PIK3CG

Gene ID:

5294

Target Species:

Human