PI3 Kinase (p110alpha/p65alpha) murine

Background Information:

PI3 Kinase plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. It also participates in cellular signaling in response to various growth factors and involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. PI3K regulates invadopodia formation through the PDPK1-AKT1 pathway, and participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others.

Target Class:

Kinase

Family:

PtdIns(4,5)P 3-Kinase

Sub Family:

Lipid

Protein Name:

PI3Kalpha

Protein Aliases:

PI3K-alpha|PI3Kalpha|PtdIns-3-kinase subunit alpha|Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|PtdIns-3-kinase subunit p110-alpha|p110alpha|Phosphoinositide-3-kinase catalytic alpha polypeptide|Serine/threonine protein kinase PIK3CA

Accession Number:

BC089038.1

UniProt Number:

P42337

Gene Name:

Pik3ca

Gene ID:

18706

Gene Aliases:

PI3K

Target Species:

Mouse