PI3 Kinase (p110alpha (H1047R)/p85alpha) murine

Background Information:

Complex of N-terminal 6His-tagged recombinant, murine full length p110α containing the mutation H1047R αand untagged, recombinant, full length murine p85α. The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and murine sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

Target Class:

Kinase

Family:

PtdIns(4,5)P 3-Kinase

Sub Family:

Lipid

Protein Name:

PI3Kalpha

Protein Aliases:

PI3K-alpha|PI3Kalpha|PtdIns-3-kinase subunit alpha|Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|PtdIns-3-kinase subunit p110-alpha|p110alpha|Phosphoinositide-3-kinase catalytic alpha polypeptide|Serine/threonine protein kinase PIK3CA

Accession Number:

NM_006218.2

UniProt Number:

P42337

Gene Name:

Pik3ca

Gene ID:

18706

Gene Aliases:

PI3K

Target Species:

Mouse