| Biological Information | |
|---|---|
| Background Information: | Phosphoinositide-Dependent Kinase-1 (PDK1) plays a central role in mediating cell signaling between PI3K and various intracellular serine/threonine kinases by phosphorylating many other kinases including PKC, p70S6 kinase, ribosomal S6 kinase, p21-activated kinase, PKC-related kinase, PKB and serum glucocorticoid kinase. PDK1 interacts with a wide range of substrates, and has been found to regulate apoptosis, cell proliferation and survival through the PI3K signaling pathway. A PDK1 inhibitor may be of therapeutic use in the treatment of human cancers and diabetes.
GenBank AF017995 |
| Target Class: | Kinase |
| Accession Number: | NM_002613.3; NM_031268.4 |
| Target Name: | PDK1 |
| Target Aliases: | PDPK1, MGC20087, PDK1, PkB-like, PRO0461, MGC35290, hPDK1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PDK1, active
N-terminal 6His-tagged recombinant, human PDK1 amino acids 52-end.
Datasheets
14-452x Datasheet
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