PDGFRbeta, active

Background Information:

Receptors that are tyrosine protein kinases include those receptors for platelet-derived growth factor (PDGF), insulin, epidermal growth factor (EGF) and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in several cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. Inhibition of PDGFRB (PDGFR1, JTK12, CD140B,Beta platelet-derived growth factor) receptor kinase may be useful in the treatment of several tumors. GenBank J03278

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

PDGFRbeta

Protein Aliases:

PDGFR-beta|Beta platelet-derived growth factor receptor|Beta-type platelet-derived growth factor receptor|CD140 antigen-like family member B|Platelet-derived growth factor receptor 1|PDGFR-1|CD antigen CD140b

Accession Number:

NM_002609.3

UniProt Number:

P09619

Gene Name:

PDGFRB

Gene ID:

5159

Gene Aliases:

JTK12|CD140b|PDGFR1|PDGFR

Target Species:

Human