PathHunter® U2OS TrkC Functional Assay

Background Information:

The PathHunter® U2OS TrkC Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkC dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged TrkC and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

TRKC

Protein Aliases:

GP145-TrkC|Trk-C|Neurotrophic tyrosine kinase receptor type 3|TrkC tyrosine kinase

Accession Number:

NM_001012338

UniProt Number:

Q16288

Gene Name:

NTRK3

Gene ID:

4916

Gene Aliases:

TRKC

Target Species:

Human

Cell Background:

U2OS