The PathHunter® U2OS RANK-IκB Functional Assay is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the NFκB pathway. This cell line enables detection of IκB levels, allowing for assessment of NFκB pathway activation-induced IκB degradation. This product uses EFC technology. The cell line included overexpresses IκB target protein fused to PL alongside untagged RANK. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of IκB EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells.
Tumor Necrosis Factor Receptor Superfamily
Tumor necrosis factor receptor superfamilymember 11a
Stable Cell Lines
Drug Discovery & Development
Short term (24 h): Store in vapor phase of liquid nitrogen.
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PathHunter® U2OS RANK-IkappaB Functional Assay
User Manuals & Protocols