PathHunter® U2OS PRβ Nuclear Translocation Cell Line

Background Information:

The PathHunter® PRβ Nuclear Translocation cell line is a stable, engineered cell line for use in studying drug candidates affecting NHR activation and nuclear translocation. This cell line enables assessment of ligand (e.g. testosterone, norgestrel) based NHR activation via detection of resulting PRβ nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged PRβ NHR and nuclear localized EA. Upon activation of PRβ, induced nuclear translocation leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

NHR

Family:

3-Ketosteroid

Sub Family:

Steroid

Protein Name:

PR

Protein Aliases:

Nuclear receptor subfamily 3 group C member 3

Accession Number:

NM_000926

UniProt Number:

P06401

Gene Name:

PGR

Gene ID:

5241

Gene Aliases:

PR|NR3C3

Target Species:

Human

Cell Background:

U2OS