PathHunter® U2OS PD-L2 Ligand Cell Line

Background Information:

The PathHunter® PD-L2 Ligand cell line is a stable, engineered cell line designed for use with PD-1 Checkpoint Signaling Cell Lines. When co-cultured, the PD-L2 expressed in this cell line will induce activity of PD-1 receptors, which may be assayed through SH2 domain protein recruitment. This product is a companion product designed to work with Immunoglobulin Superfamily Checkpoint Assays. The cell line included overexpresses PD-L2 cell surface ligand. When co-cultured with the corresponding Checkpoint Signaling Cell Line, the PD-L2 ligand binds to the checkpoint receptor, inducing receptor activity. This receptor activity leads to recruitment of the relevant SH2 domain protein to the checkpoint receptor inside the receptor cell line and production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor Ligand

Protein Name:

PD-L2

Protein Aliases:

B7 dendritic cell molecule|PD-1 ligand 2|PDCD1 ligand 2|Programmed death ligand 2|Butyrophilin B7-DC (B7-DC)|CD273

Accession Number:

NM_025239.3

UniProt Number:

Q9BQ51

Gene Name:

PDCD1LG2

Gene ID:

80380

Gene Aliases:

PD-L2|Btdc|PDL2|bA574F11.2|CD273|B7-DC|B7DC|PDCD1L2

Target Species:

Human

Cell Background:

U2OS