PathHunter® U2OS PD-L1/PD-L1 Dimerization Cell Line

Background Information:

The PathHunter® PD-L1/PD-L1 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. anti PD-L1 antibody) induced dimerization of PD-L1/PD-L1 receptors. This product uses EFC technology. The cell line included overexpresses PD-L1 target protein fused to PK alongside PD-L1 target protein fused to EA. Upon ligand-induced dimerization of PD-L1/PD-L1 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor Ligand

Protein Name:

PD-L1

Protein Aliases:

PDCD1 ligand 1|CD274 molecule|B7 homolog 1|B7-H1|CD antigen CD274

Accession Number:

NM_014143.3

UniProt Number:

Q9NZQ7

Gene Name:

CD274

Gene ID:

29126

Gene Aliases:

B7H1|PDCD1L1|PDCD1LG1|PDL1

Target Species:

Human

Cell Background:

U2OS